GeneTex

  • Country / Location Selection

United States (US)

Presenilin 2 antibody

Anti-Presenilin 2 antibody used in Western Blot (WB). GTX18041

Cat. No. GTX18041

Host

 Chicken

Clonality

 Polyclonal

Isotype

 IgY

Application

 WB, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
250 μg ($399)
See all Presenilin 2 products

APPLICATION

Application Note

ELISA: 1/1000 - 1/4000. IHC: Use at an assay dependent dilution. WB: 1/1000 - 1/4000. Predicted molecular weight: 54 kDa. To minimize background staining, we suggest using higher content of detergent (Tween-20) in dilutions of the antibody and washing. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

50 kDa. ( Note )

PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Two synthetic peptides (Human).

Purification

IgY fraction

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

presenilin 2 , AD3L , AD4 , CMD1V , PS2 , STM2

Cellular Localization

Endoplasmic reticulum membrane , Golgi apparatus membrane

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Presenilin 2 antibody used in Western Blot (WB). GTX18041

GTX18041 WB Image

Western blot analysis of mouse brain extract (20ug/lane total protein) with chicken anti presenilin 1 (Lane 2) and chicken anti presenilin 2 (GTX18041) (Lane 3)

REFERENCE

There are currently no references for Presenilin 2 antibody (GTX18041). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Presenilin 2 antibody (GTX18041). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399